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KMID : 0525720160210040247
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Journal of Chitin and Chitosan
2016 Volume.21 No. 4 p.247 ~ p.254
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Soft Corals Collected from Jeju Island; a Potential Source of Anti-inflammatory Phytochemicals
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Wang Lei
Oh Jae-Young
Fernando I. P. Shanura
Sanjeewa K. K. Asanka
Kim Eun-A
Lee Won-Woo
Jeon You-Jin
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Abstract
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Soft corals are a remarkable group of marine organisms, containing diverse array of secondary metabolites with biofunctional properties. The purpose of this study was to evaluate the potential theraputic properties of the ethanol extracts of soft coral collected from the Jeju Island against lipopolysaccharide (LPS) stimulated macrophage inflammation. The ethanol extracts of the soft corals Dendronephthya gigantea, Dendronephthya puetteri, Dendronephthya aurea, Scleronephthya gracillimum, and Chromonephthea hirotai exhibited more significantly inhibitory effects against nitric oxide (NO) generation stimulated by LPS in macrophages compared to the others. Moreover, these extracts significantly decrease the expression of interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and prostaglandin E2 (PGE2). Moreover, they also suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) could be observed. With further investigation, these soft corals could potentially provide the insight to develop anti-inflammatory compounds with clinical applications.
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KEYWORD
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Marine resource, Soft coral, Anti-inflammatory
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